Asset Details
Do you wish to reserve the book?
Incidence of bowel wall oedema on computed tomography exams and association with diarrhoea in renal cell carcinoma patients treated with sunitinib
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Incidence of bowel wall oedema on computed tomography exams and association with diarrhoea in renal cell carcinoma patients treated with sunitinib
Do you wish to request the book?
Incidence of bowel wall oedema on computed tomography exams and association with diarrhoea in renal cell carcinoma patients treated with sunitinib
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Incidence of bowel wall oedema on computed tomography exams and association with diarrhoea in renal cell carcinoma patients treated with sunitinib
2015
Overview
Objectives
The purpose of this study was to retrospectively assess the incidence of bowel wall oedema on computed tomography (CT) in patients with renal cell carcinoma (RCC) treated with sunitinib, and to investigate its association with diarrhoea.
Methods
We conducted a retrospective analysis of all RCC patients treated with sunitinib at our hospital between December 2005 and December 2011. The presence or absence of bowel wall oedema on these CT examinations was scored. The presence of diarrhoea preceding, during, or after sunitinib treatment was identified from the patient files and retrospectively graded.
Results
For 54 of 87 patients, bowel wall oedema was present on at least one CT examination. Of these 54 patients, the right-sided colonic segment was affected in 87 %. Diarrhoea was the most common reported adverse event during treatment, with 58 patients (67 %) having grade 1/2 diarrhoea and 9 patients (10 %) having grade 3. There was a statistically significant correlation between the incidence of CT-scored bowel oedema and diarrhoea during sunitinib treatment (
P
= 0.004).
Conclusions
This study shows a very high incidence of bowel wall oedema and a strong correlation between the incidence of bowel wall oedema and diarrhoea in patients treated with sunitinib.
Key Points
•
Sunitinib is routinely used in patients with advanced renal cell carcinoma
.
•
Diarrhoea is the most common reported adverse event during sunitinib treatment
.
•
Incidence of bowel oedema and diarrhoea during sunitinib treatment is correlated
.
•
Radiologists should avoid misinterpretation of bowel oedema as infectious colitis
.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - drug therapy
/ Diarrhea
/ Diarrhea - chemically induced
/ Diarrhea - diagnostic imaging
/ Edema
/ Female
/ Humans
/ Imaging
/ Intestines - diagnostic imaging
/ Kidney Neoplasms - complications
/ Kidney Neoplasms - drug therapy
/ Male
/ Medicine
/ Multidetector Computed Tomography - methods
/ Oncology
/ Patients
