Asset Details
Do you wish to reserve the book?
3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration
Do you wish to request the book?
3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration
2025
Overview
Adipose tissue engineering offers a promising approach for breast reconstruction, yet achieving efficient adipose regeneration remains challenging due to poor cell survival and tissue integration. Hence, we developed a three-dimensional (3D) electrospun collagen nanofiber scaffold integrated with adipose-derived mesenchymal stem cells (ADSCs), designed to enhance adipose tissue regeneration by providing a biomimetic extracellular matrix environment. The incorporation of collagen nanofibers enhances cell adhesion and extracellular matrix remodeling, further promoting adipogenic differentiation. Compared to conventional two-dimensional (2D) culture, ADSCs seeded on the scaffold exhibit significantly improved viability and lipid accumulation. In vivo implantation in a rat model demonstrated that the COL-ADSCs composite scaffold increased subcutaneous fat thickness from 2.69 ± 0.10 mm to 3.37 ± 0.11 mm over four weeks, while also promoting collagen remodeling and angiogenesis, as confirmed by CD31-positive staining. Despite these promising outcomes, this study is limited to a small animal model, and further validation in large animal models and clinical settings is necessary. These findings indicate that the COL-ADSCs composite scaffold provides a biomimetic microenvironment that supports ADSC adhesion, differentiation, and tissue remodeling, highlighting its potential as a clinically applicable biomaterial for breast reconstruction.
Publisher
Nature Publishing Group UK,Nature Portfolio
