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Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model
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Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model
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Journal Article
Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model
2023
Overview
The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as
Sitagliptin phosphate
) in supercritical carbon dioxide (scCO
2
) was determined by ananalytical and dynamic technique at different temperatures (308, 318, 328 and 338 K) and pressure (12–30 MPa) values. The measured solubilities were in the range of 3.02 × 10
–5
to 5.17 × 10
–5
, 2.71 × 10
–5
to 5.83 × 10
–5
, 2.39 × 10
–5
to 6.51 × 10
–5
and 2.07 × 10
–5
to 6.98 × 10
−5
in mole fraction at (308, 318, 328 and 338) K, respectively. The solubility data were correlated with existing density models and with a new association model.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
