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Long-term exposure to ambient PM1 accelerates biological aging in middle-aged and older adults in China
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Long-term exposure to ambient PM1 accelerates biological aging in middle-aged and older adults in China
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Journal Article
Long-term exposure to ambient PM1 accelerates biological aging in middle-aged and older adults in China
2025
Overview
Population aging poses significant public health challenges in China. Emerging studies have linked air pollution to physiological aging, yet evidence regarding particulate matter with an aerodynamic diameter ≤ 1 μm (PM
1
) remains sparse. This two-wave panel study included 5391 Chinese adults aged 45–80 to explore the effects of long-term exposure to PM
1
on biological aging acceleration. The Klemera−Doubal method (KDM) was employed to estimate biological aging acceleration (KDM-BAA) using 11 clinical biomarkers at both the 2011 baseline and the 2015 follow-up survey. Multivariate linear models with natural cubic splines were performed to estimate the association between PM
1
exposure and KDM-BAA changes from baseline to follow-up. Sensitivity analyses and stratified analyses were also performed. The exposure–response curve indicated that exposure to ambient PM
1
was significantly positively associated with changes in KDM-BAA, with the association becoming substantially stronger when PM
1
exposure exceeded the median exposure level of 32.5 μg/m
3
. Per 10 μg/m
3
increment in PM
1
exposure was associated with an acceleration of 1.55 (95% CI: 0.79, 2.31) years in KDM-BAA. Elderly adults over 60 years and smokers demonstrated greater susceptibility to the aging effects of ambient PM
1
exposure, whereas leisure engagement was observed to have a beneficial effect in mitigating the aging response of PM
1
exposure. Long-term exposure to ambient PM
1
may accelerate biological aging among middle-aged and older adults in China, especially in the elderly. These findings highlight the urgency for policies aimed at mitigating PM
1
pollution to promote healthy aging within an increasingly aging population.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 704/172
/ Adults
/ Aging
/ Blood
/ Exposure
/ Exposure-response relationship
/ Humanities and Social Sciences
/ PM1
/ Science
