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Selfish chromosomes exploit a germline checkpoint to eliminate competing gametes
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Journal Article
Selfish chromosomes exploit a germline checkpoint to eliminate competing gametes
2026
Overview
Spermatid individualization is a common stage of spermiogenic failure suggesting that a male germline checkpoint may act at this stage during sperm development in
Drosophila
. However, the molecular identity of such a male germline checkpoint has remained elusive. Here, we show that
Overdrive
(
Ovd
), a gene dispensable for male fertility, is required for the selective elimination of post-meiotic spermatids targeted by selfish chromosomes. Gamete elimination occurs during the individualization stage of spermiogenesis, following histone-to-protamine transition failure of targeted spermatids. We show that
Ovd
is necessary for the selfish behavior of segregation distorters across distantly related
Drosophila
species, indicating that independent selfish chromosomes use common mechanisms. Our study suggests that the normal function of an
Ovd-
mediated germline checkpoint involves the elimination of abnormal gametes during male germline development, which is exploited by selfish chromosomes into eliminating competing sperm.
A hidden quality-control system to filter out defective sperm during development is exploited by selfish genes to eliminate competing chromosomes.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 42/35
/ 42/41
/ 45/77
/ 64/24
/ Animals
/ Chromosomes, Insect - genetics
/ CRISPR
/ Drosophila melanogaster - genetics
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Females
/ Gametes
/ Genes
/ Histones
/ Humanities and Social Sciences
/ Insects
/ Kinases
/ Male
/ Males
/ Meiosis
/ Mutation
/ Ratios
/ Science
/ Sperm
