Asset Details
Do you wish to reserve the book?
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Do you wish to request the book?
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
2021
Overview
Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked, microporous scaffolds composed of microgel building blocks and were previously shown to accelerate wound healing. To promote more extensive tissue ingrowth before scaffold degradation, we aimed to slow MAP degradation by switching the chirality of the crosslinking peptides from
l
- to
d
-amino acids. Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro,
d
-peptide crosslinked MAP hydrogel (
d
-MAP) hastened material degradation in vivo and imparted significant tissue regeneration to healed cutaneous wounds, including increased tensile strength and hair neogenesis. MAP scaffolds recruit IL-33 type 2 myeloid cells, which is amplified in the presence of
d
-peptides. Remarkably,
d
-MAP elicited significant antigen-specific immunity against the
d
-chiral peptides, and an intact adaptive immune system was required for the hydrogel-induced skin regeneration. These findings demonstrate that the generation of an adaptive immune response from a biomaterial is sufficient to induce cutaneous regenerative healing despite faster scaffold degradation.
Microporous annealed-particle degradable scaffolds have been developed and shown to induce type 2 innate and adaptive immune response that facilitated skin wound healing.
Publisher
Nature Publishing Group UK,Nature Publishing Group
