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A nationwide study of the incidence rate of herb-induced liver injury in Korea
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A nationwide study of the incidence rate of herb-induced liver injury in Korea
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A nationwide study of the incidence rate of herb-induced liver injury in Korea
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Journal Article
A nationwide study of the incidence rate of herb-induced liver injury in Korea
2017
Overview
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7. All these participants were women and developed the hepatocellular type of HILI. One HILI participant met the criteria for
Hy
’s law; however, none of six cases presented clinical symptoms related to liver injury. This is the first nationwide prospective study that estimated the extent of the incidence of HILI [total: 0.60%, 95% confidence interval (CI) 0.12–1.08; women: 0.95%, 95% CI 0.19–1.68] and described its features in hospitalized participants.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Biomedical and Life Sciences
/ Chemical and Drug Induced Liver Injury - enzymology
/ Chemical and Drug Induced Liver Injury - epidemiology
/ Criteria
/ Drugs
/ Drugs, Chinese Herbal - adverse effects
/ Female
/ Females
/ Herbs
/ Humans
/ Injuries
/ Liver
/ Male
/ Males
