Journal Article

Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice

Senthilkumar, Raju, Antala, BhaveshV, Lahkar, Mangala, Patel, ManishS, Dowerah, Ena

2014

Overview

Pogostemon benghalensis has been used traditionally as anticancer in India. The present study was undertaken to investigate the antitumor activity of hydroethanolic extract of P. benghalensis (HEEPB) and aqueous extract of P. benghalensis (AEPB) on ehrlich ascites carcinoma (EAC) tumor bearing mice. For antitumor effect, treatments with HEEPB and AEPB at doses of 250 mg/kg and 500 mg/kg/day orally were started after 24 h of intraperitoneal inoculation of EAC cells. After the treatment period, median survival time (MST), hematological parameters and solid tumor volume were used to evaluate antitumor activity of the extracts. Both, HEEPB and AEPB, have increased MST (P<0.05), reduced solid tumor volume (P<0.05) and normalized hematological parameters (P<0.05) significantly. As HEEPB and AEPB were effective in reducing the severity of morphological and biochemical parameters induced by EAC cells, this study justifies the traditional use of this plant in cancer.

• Publisher: Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd
• Subject: Administration, Oral / Albinism / Animals / Antineoplastic Agents, Phytogenic - chemistry / Antioxidants - metabolism / Apiaceae - chemistry / Ascites / Cancer / Cancer therapies / Carcinoma / Carcinoma - drug therapy / Carcinoma, Ehrlich Tumor - drug therapy / Care and treatment / Chemical properties / Chemotherapy / Diffusion / Drug dosages / Drug Screening Assays, Antitumor / Ethanol / Female / Flavonoids / Health aspects / India / Laboratories / Medical examination / Mice / Neoplasm Transplantation / Oregano / Physiological aspects / Phytotherapy / Plant Extracts - chemistry / Plant Leaves - chemistry / Prevention / Risk factors / Tumors