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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
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Journal Article
C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer
2022
Overview
Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer cells. However, the cancer cell-autonomous mechanisms underlying this correlation are not well defined. Here we demonstrate that obesity-associated tumor formation is driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population. While there is no correlation with specific mutations, cellular adaptation to obesity is governed by palmitic acid (PA) and leads to enhanced tumor formation capacity of breast cancer cells. This process is governed epigenetically through increased chromatin occupancy of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPB). Obesity-induced epigenetic activation of C/EBPB regulates cancer stem-like properties by modulating the expression of key downstream regulators including
CLDN1
and
LCN2
. Collectively, our findings demonstrate that obesity drives cellular adaptation to PA drives tumor initiation in the obese setting through activation of a C/EBPB dependent transcriptional network.
Obesity is linked to cancer risk in post-menopausal breast cancer. At the molecular level this is governed by cellular adaption to palmitic acid through epigenetic activation of a C/EBPB-dependent transcriptional network that drives tumor formation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 13/89
/ 14
/ 14/34
/ 38
/ 38/15
/ 38/61
/ 38/91
/ 45
/ 59
/ 64/60
/ Adult
/ Aged
/ Animals
/ Breast Neoplasms - metabolism
/ CCAAT-Enhancer-Binding Protein-beta - genetics
/ CCAAT-Enhancer-Binding Protein-beta - metabolism
/ CCAAT/enhancer-binding protein
/ Female
/ Gene Expression Regulation, Neoplastic
/ Hormones
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Mutation
/ Obesity
/ Science
/ Tumors
