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Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
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Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
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Journal Article
Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy
2019
Overview
Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective retinal angiogenesis and associated complications that can result in vision loss. Defective Wnt/β-catenin signaling is an established cause of FEVR, whereas other molecular alterations contributing to the disease remain insufficiently understood. Here, we show that integrin-linked kinase (ILK), a mediator of cell-matrix interactions, is indispensable for retinal angiogenesis. Inactivation of the murine
Ilk
gene in postnatal endothelial cells results in sprouting defects, reduced endothelial proliferation and disruption of the blood-retina barrier, resembling phenotypes seen in established mouse models of FEVR. Retinal vascularization defects are phenocopied by inducible inactivation of the gene for α-parvin (
Parva
), an interactor of ILK. Screening genomic DNA samples from exudative vitreoretinopathy patients identifies three distinct mutations in human
ILK
, which compromise the function of the gene product in vitro. Together, our data suggest that defective cell-matrix interactions are linked to Wnt signaling and FEVR.
Integrin-linked kinase (ILK) is an important mediator of integrin signaling. Here Park et al. show that mice with endothelial-specific deletion of
Ilk
develop vascular defects that resemble familial exudative vitreoretinopathy, and identify mutations in
ILK
in patients with exudative vitreoretinopathy suggesting a potential role in human pathogenesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/51
/ 64/60
/ Animals
/ Blood-Retinal Barrier - metabolism
/ Defects
/ DNA
/ Endothelial Cells - cytology
/ Endothelial Cells - metabolism
/ Familial Exudative Vitreoretinopathies - genetics
/ Familial exudative vitreoretinopathy
/ Female
/ Human Umbilical Vein Endothelial Cells
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Male
/ Mice
/ Microfilament Proteins - genetics
/ Mutation
/ Neovascularization, Physiologic - genetics
/ Protein-Serine-Threonine Kinases - genetics
/ Retina
/ Retinal Vessels - growth & development
/ Science
