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Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver
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Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver
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Journal Article
Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver
2017
Overview
Liver granulomatous inflammation and fibrosis were the primary pathological changes observed during
Schistosoma japonicum (S. japonicum)
infection. In the present study, the characteristics of IL-9 were investigated in the liver of
S. japonicum
infection C57BL/6 mice. Immunofluorescence, qRT-PCR, and ELISA results demonstrated that the expression of IL-9 significantly increased after infection (
P
< 0.01). FACS results indicated that the peak of IL-9
+
Th9 cells in the liver mononuclear cells appeared at the early phase of infection (week 5), except that Th9 cells, CD8
+
Tc cells, NKT and γδT cells could secrete IL-9 in this model. Although IL-9 neutralization has a limited effect on liver granulomatous inflammation, it could decrease the level of fibrosis-associated factor, PC-III, in the serum of infected mice (
P
< 0.05). Taken together, our results indicated that IL-9 was an important type of cytokine involved in the progression of
S. japonicum
infection-induced hepatic damage.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/1
/ 13/21
/ 13/31
/ 64/60
/ Animals
/ Enzyme-linked immunosorbent assay
/ Female
/ Fibrosis
/ Humanities and Social Sciences
/ Liver
/ Liver Cirrhosis - metabolism
/ Liver Cirrhosis - parasitology
/ Rodents
/ Schistosoma japonicum - physiology
/ Schistosomiasis japonica - genetics
/ Schistosomiasis japonica - metabolism
/ Schistosomiasis japonica - parasitology
/ Science
