Journal Article

CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes

Abbas, Mustansar, Asif, Rizwan, Sharif, Aneeqa, Atif, Muhammad, Saeed, Hina, Hameed, Yasir, Saeed, Saba, Sial, Nuzhat, Asif, Hafiz Muhammad, Tanveer, Rida, Ahmad, Mukhtiar, Khan, Muhammad Rashid, Iqbal, Muhammad Junaid, Hussain, Muhammad Safdar, Rehman, Jalil Ur, Khan, Mehran, Hameed, Zahid

2021

Overview

According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. In the current study, we analyzed and validated the CTHRC1 expression variations in 24 different human cancer tissues paired with normal tissues using publically available databases. We observed that CTHRC1 was overexpressed in all the 24 major subtypes of human cancers and its overexpression was significantly associated with the reduced overall survival (OS) duration of head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), stomach adenocarcinoma (STAD), and Uterine corpus endometrial carcinoma (UCEC). This implies that CTHRC1 plays a significant role in the development and progression of these cancers. We further noticed that CTHRC1 was also overexpressed in HNSC, KIRC, LIHC, LUAD, STAD, and UCEC patients of different clinicopathological features. Pathways enrichment analysis revealed the involvement of CTHRC1 associated genes in seven diverse pathways. We also explored few interesting correlations between CTHRC1 expression and promoter methylation, genetic alterations, CNVs, CD8+ T immune cells infiltration, and tumor purity. In conclusion, CTHRC1 can serve as a shared diagnostic and prognostic biomarker in HNSC, KIRC, LIHC, LUAD, STAD, and UCEC patients of different clinicopathological features.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 631/114 / 631/61 / 631/67 / 631/80 / Adenocarcinoma / Antineoplastic Agents - pharmacology / Antineoplastic Agents - therapeutic use / Biomarkers / Biomarkers, Tumor / Cancer / CD8 antigen / CD8-Positive T-Lymphocytes / Collagen / Computational Biology - methods / Databases, Genetic / Disease Susceptibility / DNA Methylation / Endometrial cancer / Endometrium / Epigenesis, Genetic / Extracellular Matrix Proteins - genetics / Extracellular Matrix Proteins - metabolism / Gastric cancer / Gene Expression / Gene Expression Profiling / Gene Expression Regulation, Neoplastic - drug effects / Head & neck cancer / Head and neck carcinoma / Hepatocellular carcinoma / Hepatocytes / Humanities and Social Sciences / Humans / Immunohistochemistry / Kaplan-Meier Estimate / Liver cancer / Lung cancer / Lung carcinoma / Metastases / multidisciplinary / Neoplasm Staging / Neoplasms - diagnosis / Neoplasms - genetics / Neoplasms - mortality / Neoplasms - therapy / Organ Specificity / Prognosis / Promoter Regions, Genetic / Protein Interaction Mapping / Renal cell carcinoma / Science / Science (multidisciplinary) / Squamous cell carcinoma / Tumor microenvironment / Tumorigenesis / Uterine cancer / Uterus