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Molecular mechanism of oil induced growth inhibition in diatoms using Thalassiosira pseudonana as the model species
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Molecular mechanism of oil induced growth inhibition in diatoms using Thalassiosira pseudonana as the model species
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Journal Article
Molecular mechanism of oil induced growth inhibition in diatoms using Thalassiosira pseudonana as the model species
2021
Overview
The 2010 Deepwater Horizon oil-spill exposed the microbes of Gulf of Mexico to unprecedented amount of oil. Conclusive evidence of the underlying molecular mechanism(s) on the negative effects of oil exposure on certain phytoplankton species such as
Thalassiosira pseudonana
is still lacking, curtailing our understanding of how oil spills alter community composition. We performed experiments on model diatom
T. pseudonana
to understand the mechanisms underpinning observed reduced growth and photosynthesis rates during oil exposure. Results show severe impairment to processes
upstream
of photosynthesis, such as light absorption, with proteins associated with the light harvesting complex damaged while the pigments were unaffected. Proteins associated with photosynthetic electron transport were also damaged, severely affecting photosynthetic apparatus and depriving cells of energy and carbon for growth. Negative growth effects were alleviated when an organic carbon source was provided. Further investigation through proteomics combined with pathway enrichment analysis confirmed the above findings, while highlighting other negatively affected processes such as those associated with ferroxidase complex, high-affinity iron-permease complex, and multiple transmembrane transport. We also show that oxidative stress is not the primary route of negative effects, rather secondary. Overall, this study provides a mechanistic understanding of the cellular damage that occurs during oil exposure to
T. pseudonana
.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
