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Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
by
Thomas, G.
, Sanders, M. E.
, Pence, I. J.
, Hooks, M.
, O’Connor, M. E.
, Nguyen, T.-Q.
, Caldwell, B.
, Grau, A.
, Kelley, M. C.
, Giltnane, J.
, Mahadevan-Jansen, A.
, Meszoely, I.
in
13/51
/ 140/125
/ 140/133
/ 631/67/1347
/ 639/166/985
/ Area Under Curve
/ Automation
/ Breast - diagnostic imaging
/ Breast cancer
/ Breast Neoplasms - diagnostic imaging
/ Breast Neoplasms - pathology
/ Breast Neoplasms - surgery
/ Cytology
/ Equipment Design
/ Feasibility Studies
/ Female
/ Histopathology
/ Humanities and Social Sciences
/ Humans
/ Imaging, Three-Dimensional - instrumentation
/ Imaging, Three-Dimensional - methods
/ Invasiveness
/ Mastectomy
/ multidisciplinary
/ Raman spectroscopy
/ ROC Curve
/ Science
/ Science (multidisciplinary)
/ Spectroscopy
/ Spectrum analysis
/ Spectrum Analysis, Raman
/ Surgery
/ Tumors
2017
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Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
by
Thomas, G.
, Sanders, M. E.
, Pence, I. J.
, Hooks, M.
, O’Connor, M. E.
, Nguyen, T.-Q.
, Caldwell, B.
, Grau, A.
, Kelley, M. C.
, Giltnane, J.
, Mahadevan-Jansen, A.
, Meszoely, I.
in
13/51
/ 140/125
/ 140/133
/ 631/67/1347
/ 639/166/985
/ Area Under Curve
/ Automation
/ Breast - diagnostic imaging
/ Breast cancer
/ Breast Neoplasms - diagnostic imaging
/ Breast Neoplasms - pathology
/ Breast Neoplasms - surgery
/ Cytology
/ Equipment Design
/ Feasibility Studies
/ Female
/ Histopathology
/ Humanities and Social Sciences
/ Humans
/ Imaging, Three-Dimensional - instrumentation
/ Imaging, Three-Dimensional - methods
/ Invasiveness
/ Mastectomy
/ multidisciplinary
/ Raman spectroscopy
/ ROC Curve
/ Science
/ Science (multidisciplinary)
/ Spectroscopy
/ Spectrum analysis
/ Spectrum Analysis, Raman
/ Surgery
/ Tumors
2017
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Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
by
Thomas, G.
, Sanders, M. E.
, Pence, I. J.
, Hooks, M.
, O’Connor, M. E.
, Nguyen, T.-Q.
, Caldwell, B.
, Grau, A.
, Kelley, M. C.
, Giltnane, J.
, Mahadevan-Jansen, A.
, Meszoely, I.
in
13/51
/ 140/125
/ 140/133
/ 631/67/1347
/ 639/166/985
/ Area Under Curve
/ Automation
/ Breast - diagnostic imaging
/ Breast cancer
/ Breast Neoplasms - diagnostic imaging
/ Breast Neoplasms - pathology
/ Breast Neoplasms - surgery
/ Cytology
/ Equipment Design
/ Feasibility Studies
/ Female
/ Histopathology
/ Humanities and Social Sciences
/ Humans
/ Imaging, Three-Dimensional - instrumentation
/ Imaging, Three-Dimensional - methods
/ Invasiveness
/ Mastectomy
/ multidisciplinary
/ Raman spectroscopy
/ ROC Curve
/ Science
/ Science (multidisciplinary)
/ Spectroscopy
/ Spectrum analysis
/ Spectrum Analysis, Raman
/ Surgery
/ Tumors
2017
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Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
Journal Article
Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment
2017
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Overview
Breast conserving surgery is the preferred treatment for women diagnosed with early stage invasive breast cancer. To ensure successful breast conserving surgeries, efficient tumour margin resection is required for minimizing tumour recurrence. Currently surgeons rely on touch preparation cytology or frozen section analysis to assess tumour margin status intraoperatively. These techniques have suboptimal accuracy and are time-consuming. Tumour margin status is eventually confirmed using postoperative histopathology that takes several days. Thus, there is a need for a real-time, accurate, automated guidance tool that can be used during tumour resection intraoperatively to assure complete tumour removal in a single procedure. In this paper, we evaluate feasibility of a 3-dimensional scanner that relies on Raman Spectroscopy to assess the entire margins of a resected specimen within clinically feasible time. We initially tested this device on a phantom sample that simulated positive tumour margins. This device first scans the margins of the sample and then depicts the margin status in relation to an automatically reconstructed image of the phantom sample. The device was further investigated on breast tissues excised from prophylactic mastectomy specimens. Our findings demonstrate immense potential of this device for automated breast tumour margin assessment to minimise repeat invasive surgeries.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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