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Encoding of long-term associations through neural unitization in the human medial temporal lobe
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Encoding of long-term associations through neural unitization in the human medial temporal lobe
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Journal Article
Encoding of long-term associations through neural unitization in the human medial temporal lobe
2018
Overview
Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP responses in the theta band preceded single neuron responses by ~70 ms, with the single trial phase providing fine tuning of the spike response onset. We postulate that the finding of similar neuronal responses to associated items provides a simple and flexible way of encoding memories in the human MTL, increasing the effective capacity for memory storage and successful retrieval.
In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in the human MTL.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 9/30
/ 9/97
/ Action Potentials - physiology
/ Adult
/ Coding
/ Electrophysiological recording
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory
/ Neurons
/ Science
/ Stimuli
