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A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

by Casimiro, Danilo R. , Tang, Aimin , Zhang, Lan , Citron, Michael P. , Govindarajan, Dhanasekaran , Eddins, Michael , DiStefano, Daniel J. , Soisson, Stephen M. , Reid, John C. , Fridman, Arthur , Wang, Dai , Vora, Kalpit A. , Heidecker, Gwendolyn J. , Su, Hua-Poo , Patel, Sangita B. , Swoyer, Ryan , Chen, Zhifeng , Luo, Bin , Cox, Kara S. , Cejas, Pedro J. , Touch, Sinoeun , Callahan, Cheryl , Galli, Jennifer , Wen, Zhiyun

in 101/1 / 631/154 / 692/308 / Animals / Antibodies, Monoclonal - isolation & purification / Antibodies, Viral - immunology / Antigens / B-Lymphocytes - immunology / Binding Sites / Broadly Neutralizing Antibodies - immunology / Clinical isolates / Conserved Sequence / Disease Models, Animal / Epitopes / Epitopes - immunology / Female / Glycoproteins / Glycoproteins - immunology / Humanities and Social Sciences / Humans / Immunologic Memory / Immunological memory / Infant mortality / Infants / Infections / Lymphocytes B / Models, Molecular / Monoclonal antibodies / multidisciplinary / Neutralizing / Prevention / Protein Binding / Respiratory syncytial virus / Respiratory Syncytial Virus, Human - immunology / Science / Science (multidisciplinary) / Sigmodontinae / Viral Fusion Proteins - immunology / Viruses

2019

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A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

2019

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2019

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Journal Article

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

Casimiro, Danilo R.,

Tang, Aimin,

Zhang, Lan,

Citron, Michael P.,

Govindarajan, Dhanasekaran,

Eddins, Michael,

DiStefano, Daniel J.,

Soisson, Stephen M.,

Reid, John C.,

Fridman, Arthur,

Wang, Dai,

Vora, Kalpit A.,

Heidecker, Gwendolyn J.,

Su, Hua-Poo,

Patel, Sangita B.,

Swoyer, Ryan,

Chen, Zhifeng,

Luo, Bin,

Cox, Kara S.,

Cejas, Pedro J.,

Touch, Sinoeun,

Callahan, Cheryl,

Galli, Jennifer,

Wen, Zhiyun

2019

Overview

Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant mortality under six months of age worldwide; therefore, the prevention of RSV infection in all infants represents a significant unmet medical need. Here we report the isolation of a potent and broadly neutralizing RSV monoclonal antibody derived from a human memory B-cell. This antibody, RB1, is equipotent on RSV A and B subtypes, potently neutralizes a diverse panel of clinical isolates in vitro and demonstrates in vivo protection. It binds to a highly conserved epitope in antigenic site IV of the RSV fusion glycoprotein. RB1 is the parental antibody to MK-1654 which is currently in clinical development for the prevention of RSV infection in infants. Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

101/1

/ 631/154

/ 692/308

/ Animals

/ Antibodies, Monoclonal - isolation & purification

/ Antibodies, Viral - immunology

/ Antigens