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Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction
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Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction
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Journal Article
Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction
2019
Overview
The interaction of light with biological tissues has been considered for various therapeutic applications. Light-induced neurite growth has the potential to be a clinically useful technique for neuron repair. However, most previous studies used either a large illumination area to accelerate overall neurite growth or employed a light spot to guide a growing neurite. It is not clear if optical stimulation can induce the regrowth of a retracted neurite. In the present work, we used blue light (wavelength: 473 nm) to cause neurite retraction, and we proved that using a red-light (wavelength: 650 nm) spot to illuminate the soma near the junction of the retracted neurite could induce neurite regrowth. As a comparison, we found that green light (wavelength 550 nm) had a 62% probability of inducing neurite regrowth, while red light had a 75% probability of inducing neurite regrowth at the same power level. Furthermore, the neurite regrowth length induced by red light was increased by the pre-treatment with inhibitors of myosin functions. We also observed actin propagation from the soma to the tip of the re-growing neurite following red-light stimulation of the soma. The red light-induced extension and regrowth were abrogated in the calcium-free medium. These results suggest that illumination with a red-light spot on the soma may trigger the regrowth of a neurite after the retraction caused by blue-light illumination.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/107
/ 692/617
/ Actin
/ Animals
/ Calcium
/ Color
/ Heterocyclic Compounds, 4 or More Rings - pharmacology
/ Humanities and Social Sciences
/ Light
/ Low-Level Light Therapy - methods
/ Mice
/ Myosin
/ Myosin Type II - antagonists & inhibitors
/ Nerve Regeneration - drug effects
/ Nerve Regeneration - radiation effects
/ Neurites - radiation effects
/ Primary Cell Culture - methods
/ Rats
/ Regrowth
/ Science
