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Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour
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Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour
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Journal Article
Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour
2020
Overview
The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in
Drosophila melanogaster, Acetobacter pomorum
(
Ap
) and
Lactobacillus plantarum
(
Lp
) a syntrophic relationship is established to overcome detrimental host diets and identify
Ap
as the bacterium altering the host’s feeding decisions. Specifically, we show that
Ap
uses the lactate produced by
Lp
to supply amino acids that are essential to
Lp
, allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for
Ap
to alter the fly’s protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets. These interactions also ensure the constant flow of metabolites used by the microbiome to alter reproduction and host behaviour.
In the fly
Drosophila melanogaster
commensal bacteria and dietary essential amino acids control food choice behavior. Here, by using chemically defined diets and metabolomics, the authors show that
Acetobacter pomorum
(
Ap
) and
Lactobacilli plantarum
(
Lp
) engage in a mutualistic metabolic relationship to overcome detrimental diets, and identify
Ap
as the bacterium altering the host’s feeding decisions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 64
/ 64/24
/ 82/58
/ Acetobacter - growth & development
/ Animals
/ Appetite
/ Bacteria
/ Diet
/ Drosophila melanogaster - microbiology
/ Drosophila melanogaster - physiology
/ Female
/ Gastrointestinal Microbiome - physiology
/ Humanities and Social Sciences
/ Insects
/ Lactobacillus plantarum - growth & development
/ Lactobacillus plantarum - metabolism
/ Mapping
/ Metabolic Networks and Pathways
/ Science
