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PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
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PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
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PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
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Journal Article
PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
2017
Overview
Ischemia/reperfusion injury triggers acute kidney injury (AKI) by aggravating oxidative stress mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master player that regulates mitochondrial biogenesis and the antioxidant response. We postulated that PGC-1α functions as cytoprotective effector in renal cells and that its regulation mechanism is coordinated by nuclear factor erythroid 2-related factor 2 (Nrf-2). In this study, to understand the effect and molecular mechanisms of PGC-1α, we developed an empty vector or PGC-1α-overexpressing stable cell lines in HK-2 cells (Mock or PGC-1α stable cells). PGC-1α overexpression increased the viability of cells affected by H
2
O
2
mediated injury, protected against H
2
O
2
-mediated apoptotic events and inhibited reactive oxygen species accumulation in the cytosol and mitochondria as compared to that in Mock cells. The cytoprotective effect of PGC-1α was related to Nrf-2 upregulation, which was counteracted by Nrf-2-specific knockdown. Using inhibitor of p38, we found that regulation of the p38/glycogen synthase kinase 3β (GSK3β)/Nrf-2 axis was involved in the protective effects of PGC-1α. Taken together, we suggest that PGC-1α protects human renal tubule cells from H
2
O
2
-mediated apoptotic injury by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 42
/ 42/41
/ 42/89
/ 96
/ 96/2
/ 96/95
/ Animals
/ Cytosol
/ Diabetes
/ Glycogen
/ Glycogen Synthase Kinase 3 beta - metabolism
/ Humanities and Social Sciences
/ Hydrogen Peroxide - pharmacology
/ Ischemia
/ Kidney Diseases - metabolism
/ Kidneys
/ Kinases
/ Male
/ Mice
/ NF-E2-Related Factor 2 - genetics
/ NF-E2-Related Factor 2 - metabolism
/ p38 Mitogen-Activated Protein Kinases - metabolism
/ Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics
/ Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
/ Proteins
/ Reperfusion Injury - genetics
/ Reperfusion Injury - metabolism
/ Reperfusion Injury - pathology
/ RNA, Small Interfering - genetics
/ Science
