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Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species
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Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species
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Journal Article
Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species
2018
Overview
Candida auris
is an emergent multidrug-resistant fungal pathogen causing increasing reports of outbreaks. While distantly related to
C. albicans
and
C. glabrata
,
C. auris
is closely related to rarely observed and often multidrug-resistant species from the
C. haemulonii
clade. Here, we analyze near complete genome assemblies for the four
C. auris
clades and three related species, and map intra- and inter-species rearrangements across the seven chromosomes. Using RNA-Seq-guided gene predictions, we find that most mating and meiosis genes are conserved and that clades contain either the
MTL
a
or
MTL
α mating loci. Comparing the genomes of these emerging species to those of other
Candida
species identifies genes linked to drug resistance and virulence, including expanded families of transporters and lipases, as well as mutations and copy number variants in
ERG11
. Gene expression analysis identifies transporters and metabolic regulators specific to
C. auris
and those conserved with related species which may contribute to differences in drug response in this emerging fungal clade.
Candida auris
is an emergent fungal pathogen that is resistant to multiple antifungals. Here, Muñoz et al. analyse genomic sequences for isolates from each of the four major
C. auris
clades and for three related species, and identify genetic features associated with virulence, antifungal resistance and mating.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/91
/ Antifungal Agents - pharmacology
/ Communicable Diseases, Emerging - drug therapy
/ Communicable Diseases, Emerging - microbiology
/ Communicable Diseases, Emerging - pathology
/ Cytochrome P-450 Enzyme System - genetics
/ Drug Resistance, Multiple, Fungal - genetics
/ Fungi
/ Genes
/ Genomes
/ Humanities and Social Sciences
/ Mating
/ Meiosis
/ Multidrug resistant organisms
/ Mutation
/ RNA
/ Science
/ Species
