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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
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Journal Article
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
2022
Overview
Cell fate commitment is driven by dynamic changes in chromatin architecture and activity of lineage-specific transcription factors (TFs). The chromatin assembly factor-1 (CAF-1) is a histone chaperone that regulates chromatin architecture by facilitating nucleosome assembly during DNA replication. Accumulating evidence supports a substantial role of CAF-1 in cell fate maintenance, but the mechanisms by which CAF-1 restricts lineage choice remain poorly understood. Here, we investigate how CAF-1 influences chromatin dynamics and TF activity during lineage differentiation. We show that CAF-1 suppression triggers rapid differentiation of myeloid stem and progenitor cells into a mixed lineage state. We find that CAF-1 sustains lineage fidelity by controlling chromatin accessibility at specific loci, and limiting the binding of ELF1 TF at newly-accessible diverging regulatory elements. Together, our findings decipher key traits of chromatin accessibility that sustain lineage integrity and point to a powerful strategy for dissecting transcriptional circuits central to cell fate commitment.
Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/31
/ 38
/ 38/15
/ 38/39
/ 38/89
/ 38/91
/ 45
/ 64
/ 64/60
/ Accuracy
/ Assembly
/ Biology
/ Blood
/ Cancer
/ Chromatin Assembly Factor-1 - genetics
/ Chromatin Assembly Factor-1 - metabolism
/ Cloning
/ Fidelity
/ Histone Chaperones - metabolism
/ Histones
/ Humanities and Social Sciences
/ Science
/ Stems
