Asset Details
Do you wish to reserve the book?
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Do you wish to request the book?
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
2019
Overview
Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The
CBFB
gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a variety of human cancers including breast cancer. Here we report a noncanonical role of CBFB in translation regulation. RNA immunoprecipitation followed by deep sequencing (RIP-seq) reveals that cytoplasmic CBFB binds to hundreds of transcripts and regulates their translation. CBFB binds to mRNAs via hnRNPK and enhances translation through eIF4B, a general translation initiation factor. Interestingly, the
RUNX1
mRNA, which encodes the transcriptional partner of CBFB, is bound and translationally regulated by CBFB. Furthermore, nuclear CBFB/RUNX1 complex transcriptionally represses the oncogenic NOTCH signaling pathway in breast cancer. Thus, our data reveal an unexpected function of CBFB in translation regulation and propose that breast cancer cells evade translation and transcription surveillance simultaneously through downregulating CBFB.
CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/91
/ 45/15
/ 82/29
/ 82/58
/ Animals
/ Breast Neoplasms - pathology
/ Cancer
/ Core Binding Factor Alpha 2 Subunit - genetics
/ Core Binding Factor Alpha 2 Subunit - metabolism
/ Core Binding Factor beta Subunit - metabolism
/ Eukaryotic Initiation Factors - metabolism
/ Female
/ Gene Expression Regulation, Neoplastic
/ Heterogeneous-Nuclear Ribonucleoprotein K - metabolism
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Receptors, Notch - metabolism
/ Science
