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A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota
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A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota
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Journal Article
A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota
2019
Overview
Bacteria often produce antimicrobial toxins to compete in microbial communities. Here we identify a family of broad-spectrum peptide toxins, named bacteroidetocins, produced by Bacteroidetes species. We study this toxin family using phenotypic, mutational, bioinformatic, and human metagenomic analyses. Bacteroidetocins are related to class IIa bacteriocins of Gram-positive bacteria and kill members of the Bacteroidetes phylum, including
Bacteroides
,
Parabacteroides
, and
Prevotella
gut species, as well as pathogenic
Prevotella
species. The bacteroidetocin biosynthesis genes are found in horizontally acquired mobile elements, which likely allow dissemination within the gut microbiota and may explain their wide distribution in human populations. Bacteroidetocins may have potential applications in microbiome engineering and as therapeutics for polymicrobial diseases such as bacterial vaginosis and periodontal disease.
Bacteria often produce antimicrobial toxins to compete in microbial communities. Here, the authors identify a family of peptide toxins that are produced by, and target, Bacteroidetes species, some of which are widespread in the human gut microbiota.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/22
/ 45/23
/ 45/29
/ 45/41
/ 45/70
/ 45/77
/ 82/1
/ 82/29
/ 82/58
/ Anti-Bacterial Agents - biosynthesis
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacterial Proteins - biosynthesis
/ Bacterial Proteins - genetics
/ Bacterial Proteins - pharmacology
/ Bacterial Toxins - biosynthesis
/ Bacterial Toxins - pharmacology
/ Bacteroidetes - drug effects
/ Female
/ Gastrointestinal Microbiome - genetics
/ Gastrointestinal Microbiome - physiology
/ Gastrointestinal Tract - microbiology
/ Gene Transfer, Horizontal - genetics
/ Humanities and Social Sciences
/ Humans
/ Interspersed Repetitive Sequences
/ Peptides
/ Science
/ Species
/ Toxins
