Asset Details
Do you wish to reserve the book?
Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders
Do you wish to request the book?
Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders
2024
Overview
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by social, behavioral, and cognitive impairments. Several comorbidities, including gastrointestinal (GI) dysregulations, are frequently reported in ASD children. Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial composition affects the pathogenesis of ASD. Moreover, disruption of the gut–brain axis (GBA) has been reported in ASD although with limited studies conducted on the Mediterranean population. In our study, we aimed to investigate gut microbiota composition in Lebanese ASD subjects, their unaffected siblings, and a control group from various regions in Lebanon using the 16 S-rRNA sequencing (NGS). Our study revealed a lower abundance of
Turicibacter
and a significant enrichment on
Proteobacteria
in the ASD and siblings’ groups compared to the controls, indicating that gut microbiota is probably affected by dietary habits, living conditions together with host genetic factors. The study also showed evidence of changes in the gut microbiome of ASD children compared to their siblings and the unrelated control.
Bacteroidetes
revealed a lower abundance in the ASD group compared to controls and siblings, conversely,
Catenibacterium
and
Tenericutes
revealed an increased abundance in the ASD group. Notably, our study identifies alterations in the abundance of
Turicibacter
and
Catenibacterium
in ASD children suggesting a possible link between these bacterial taxa and ASD and contributing to the growing body of evidence linking the microbiome to ASD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Autism
/ Autism Spectrum Disorder - microbiology
/ Child
/ Children
/ Female
/ Gastrointestinal dysregulations
/ Gastrointestinal Microbiome - genetics
/ Humanities and Social Sciences
/ Humans
/ Lebanon
/ Male
/ Neurodevelopmental disorders
/ RNA, Ribosomal, 16S - genetics
/ rRNA
/ Science
/ Siblings
