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The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria
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The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria
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Journal Article
The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria
2025
Overview
Malaria-associated acute kidney injury (MAKI) is a common complication of
Plasmodium
infection, affecting ~ 50% of severe malaria cases and associated with increased mortality. However, its immunopathogenesis remains unclear. Interferon-gamma (IFN-gamma) is a crucial cytokine that influences parasite clearance and mediates pathogenesis in experimental models of malaria. This study explored the role of IFN-gamma in kidney pathology in C57BL/6 mice infected with
Plasmodium berghei
NK65 (
Pb
NK65) and
P. chabaudi
AS (
Pc
AS).
Pb
NK65-infected mice, normally susceptible to severe malaria, were protected from both MAKI and malaria-associated acute respiratory distress syndrome (MA-ARDS) when lacking IFN-gamma. Infected IFN-gamma knockout (KO) mice developed low parasitemia levels, minimal kidney histopathological changes and reduced expression of the kidney injury marker Neutrophil Gelatinase-Associated Lipocalin (NGAL). In contrast, upon
Pc
AS-infection, IFN-gamma deficiency led to increased parasitemia and aggravated kidney pathology, evidenced by proteinuria, hyaline casts in kidneys and increased renal mRNA expression of Heme Oxygenase 1 (HO
-
1) and NGAL. In both models, IFN-gamma induced renal C-X-C Motif Chemokine Ligand 10 (CXCL10) but did not affect Tumor Necrosis Factor-alpha (TNF-alpha) expression. Our data indicate that IFN-gamma exerts a dual effect on kidney pathology, which is conditioned by the mouse model and its impact on parasitemia.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Acute Kidney Injury - etiology
/ Acute Kidney Injury - metabolism
/ Acute Kidney Injury - parasitology
/ Acute Kidney Injury - pathology
/ Animals
/ Heme oxygenase (decyclizing)
/ Heme Oxygenase-1 - metabolism
/ Humanities and Social Sciences
/ IFN-γ
/ Interferon-gamma - deficiency
/ Interferon-gamma - metabolism
/ Kidneys
/ Malaria
/ Mice
/ Respiratory distress syndrome
/ Science
