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Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration
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Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration
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Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration
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Journal Article
Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration
2024
Overview
Intervertebral disc degeneration is a natural process during aging and a leading cause of lower back pain. Here, we generate a comprehensive atlas of nucleus pulposus cells using single-cell RNA-seq analysis of human nucleus pulposus tissues (three males and four females, age 41.14 ± 18.01 years). We identify fibrotic late-stage nucleus pulposus cells characterized by upregulation of serglycin expression which facilitate the local inflammatory response by promoting the infiltration of inflammatory cytokines and macrophages. Finally, we discover that daphnetin, a potential serglycin ligand, substantially mitigates the local inflammatory response by downregulating serglycin expression in an in vivo mouse model, thus alleviating intervertebral disc degeneration. Taken together, we identify late-stage nucleus pulposus cells and confirm the potential mechanism by which serglycin regulates intervertebral disc degeneration. Our findings indicate that serglycin is a latent biomarker of intervertebral disc degeneration and may contribute to development of diagnostic and therapeutic strategies.
Aging-related intervertebral disc degeneration (IVDD) is a leading cause of lower back pain. Here, the authors perform scRNA-seq analysis of intervertebral disc cells from patients, and identify cell populations and mechanisms associated with IVDD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/21
/ 13/31
/ 13/51
/ 38
/ 49/91
/ 59/57
/ 692/699
/ Adult
/ Aging
/ Animals
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intervertebral Disc - metabolism
/ Intervertebral Disc Degeneration - metabolism
/ Male
/ Mice
/ Nucleus Pulposus - metabolism
/ Pain
/ Science
