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Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection
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Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection
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Journal Article
Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection
2024
Overview
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain elusive. Here, we elucidate the pivotal role of CD47 in the airway epithelium during bacterial super-infection. We demonstrated that upon influenza virus infection, CD47 expression was upregulated and localized on the apical surface of ciliated cells within primary human nasal or bronchial epithelial cells. This induced CD47 exposure provided attachment sites for
Staphylococcus aureus
, thereby compromising the epithelial barrier integrity. Through bacterial adhesion assays and in vitro pull-down assays, we identified fibronectin-binding proteins (FnBP) of
S. aureus
as a key component that binds to CD47. Furthermore, we found that ciliated cell-specific CD47 deficiency or neutralizing antibody-mediated CD47 inactivation enhanced in vivo survival rates. These findings suggest that interfering with the interaction between airway epithelial CD47 and pathogenic bacterial FnBP holds promise for alleviating the adverse effects of super-infection.
During the influenza pandemic, a large number of deaths resulted from secondary bacterial pneumonia caused by common upper respiratory tract bacteria, such as
Staphylococcus
. Here, Moon et al, find that the interaction between airway epithelial CD47 and the pathogenic bacterial FnBP is critical in causing bacterial superinfection.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 38
/ 38/88
/ 64
/ 64/60
/ 82/80
/ Animals
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Epithelial Cells - metabolism
/ Epithelial Cells - microbiology
/ Humanities and Social Sciences
/ Humans
/ Influenza A Virus, H1N1 Subtype
/ Influenza, Human - immunology
/ Influenza, Human - metabolism
/ Mice
/ Orthomyxoviridae Infections - immunology
/ Orthomyxoviridae Infections - metabolism
/ Orthomyxoviridae Infections - virology
/ Respiratory Mucosa - metabolism
/ Respiratory Mucosa - microbiology
/ Respiratory Mucosa - virology
/ Science
/ Staphylococcal Infections - immunology
/ Staphylococcal Infections - metabolism
/ Staphylococcal Infections - microbiology
/ Superinfection - microbiology
/ Survival
