Asset Details
Do you wish to reserve the book?
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Do you wish to request the book?
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
2021
Overview
GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to stable performance of complex behaviors. Here, we found that genetic ablation of GABA
B
receptors in medial prefrontal cortex astrocytes altered low-gamma oscillations and firing properties of cortical neurons, which affected goal-directed behaviors. Remarkably, working memory deficits were restored by optogenetic stimulation of astrocytes with melanopsin. Furthermore, melanopsin-activated astrocytes in wild-type mice enhanced the firing rate of cortical neurons and gamma oscillations, as well as improved cognition. Therefore, our work identifies astrocytes as a hub for controlling inhibition in cortical circuits, providing a novel pathway for the behaviorally relevant midrange time-scale regulation of cortical information processing and consistent goal-directed behaviors.
Mederos et al. show that GABA
B
receptor signaling in astrocytes regulates prefrontal cortex activity to impact goal-directed behaviors. Thus, the coordinated activity of GABAergic neurons and astrocytes helps decision-making.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Ablation
/ Animal Genetics and Genomics
/ Animals
/ Behavior
/ Biomedical and Life Sciences
/ Brain
/ Cellular signal transduction
/ GABA
/ GABAergic Neurons - physiology
/ gamma-Aminobutyric Acid - physiology
/ Goals
/ Memory, Short-Term - physiology
/ Mice
/ Neurons
/ Prefrontal Cortex - physiology
/ Psychomotor Performance - physiology
/ Receptors, GABA-B - genetics
/ Receptors, GABA-B - physiology
/ Signal Transduction - physiology
/ Synapses
