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Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior
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Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior
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Journal Article
Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior
2017
Overview
Inputs to midbrain dopamine neurons control rewarding and drug-related behaviors. The authors found that nucleus accumbens inputs and local GABA neurons inhibit dopamine neurons through distinct populations of GABA receptors. Furthermore, genetic deletion of GABA
B
receptors from dopamine neurons selectively increased behavioral sensitivity to cocaine.
Afferent inputs to the ventral tegmental area (VTA) control reward-related behaviors through regulation of dopamine neuron activity. The nucleus accumbens (NAc) provides one of the most prominent projections to the VTA; however, recent studies have provided conflicting evidence regarding the function of these inhibitory inputs. Using optogenetics, cell-specific ablation, whole cell patch-clamp and immuno-electron microscopy, we found that NAc inputs synapsed directly onto dopamine neurons, preferentially activating GABA
B
receptors. GABAergic inputs from the NAc and local VTA GABA neurons were differentially modulated and activated separate receptor populations in dopamine neurons. Genetic deletion of GABA
B
receptors from dopamine neurons in adult mice did not affect general or morphine-induced locomotor activity, but markedly increased cocaine-induced locomotion. Collectively, our findings demonstrate notable selectivity in the inhibitory architecture of the VTA and suggest that long-range GABAergic inputs to dopamine neurons fundamentally regulate behavioral responses to cocaine.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 64/60
/ 9/74
/ Animal Genetics and Genomics
/ Animals
/ Behavior
/ Cocaine
/ Dopamine
/ Dopaminergic Neurons - physiology
/ Dopaminergic Neurons - ultrastructure
/ Female
/ Male
/ Mice
/ Morphine
/ Neural Inhibition - physiology
/ Neurons
/ Nucleus Accumbens - physiology
/ Receptor, Adenosine A1 - physiology
/ Receptors, GABA-A - physiology
/ Receptors, GABA-B - biosynthesis
/ Receptors, GABA-B - genetics
/ Receptors, GABA-B - physiology
/ Reward
/ Roles
/ Synaptic Transmission - physiology
