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Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male albino rats
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Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male albino rats
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Journal Article
Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male albino rats
2025
Overview
Sr
2
NiCoAl
0.3
Fe
27.7
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46
X-Type hexa-nano-ferrites were prepared using a co-precipitation route, coated with Chitosan, and synthesized into a ferrite chitosan curcumin nanoparticle system. This combination enhances curcumin’s therapeutic properties, chitosan’s bioavailability, and ferrite’s magnetic targeting potential, offering improved cellular uptake and diagnostic applications. Nandrolone decanote (ND), one of the class II anabolic androgenic steroids (AASs), quickly spreading as a class of medications used in both clinical and illegal settings. AAS can enhance tolerance to exercise, so they are taken illegally by bodybuilders and adolescents. However, the abuse of AASs can lead to serious and irreversible organ toxicity. This study designed to investigate the therapeutics effect of nano ferrite chitosan curcumin nanoparticles (NF-CH-CurNPs) against ND induced hepatic toxicity, proliferation, inflammation, oxidative stress, and DNA damage in male rats. 48 adult male rats assigned to 6 groups [1st Gp, control; 2nd Gp, CurNPs; 3rd Gp, NF-CH-CurNPs; 4th Gp, ND; 5th Gp, ND + CurNPs; 6th Gp. ND + NF-CH-CurNPs]. Current results revealed, a significant elevation in the levels of aspartate transaminase (AST), alanine transaminase (ALT), total proteins, liver DNA damage, injury, malondialdehyde (MDA), proliferating cell nuclear antigen (PCNA), tumor necrosis factor alpha (TNFα) and a significant depletion in albumin, catalase, superoxide dismutase (SOD), reduced glutathione (GSH) after ND administration as compared to control and CurNPs groups. Treatment of ND with CurNPs or NF-CH-CurNPs significantly improved liver functions, structure, oxidative stress, DNA damage, PCNA, and TNFα expressions, with NF-CH-CurNPs showing potential for scavenging free radicals.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/80
/ Animals
/ Blood
/ Chemical and Drug Induced Liver Injury - drug therapy
/ Chemical and Drug Induced Liver Injury - etiology
/ Chemical and Drug Induced Liver Injury - metabolism
/ Chemical and Drug Induced Liver Injury - pathology
/ Chitosan
/ Curcumin
/ DNA
/ Ethanol
/ Ferric Compounds - chemistry
/ Humanities and Social Sciences
/ Liver
/ Male
/ Nandrolone Decanoate - toxicity
/ Nano ferrite-chitosan-curcumin nanoparticles
/ Nitrates
/ Oxidative Stress - drug effects
/ PCNA
/ Proliferating cell nuclear antigen
/ Rats
/ Scanning electron microscopy
/ Science
/ Steroids
/ TNFα
/ Toxicity
