Journal Article

Diagnostic work-up in periprosthetic joint infections of the knee: can the albumin-to-globulin ratio be a screening tool?

Innocenti, Matteo, Di Pace, Edoardo, Rosito, Sara, Ascione, Tiziana, Balato, Giovanni, Festa, Enrico, Leggieri, Filippo, Marasco, Lucrezia, De Mauro, Domenico

2025

Overview

Background This study aimed to assess the most appropriate thresholds for albumin-to-globulin ratio (AGR) in patients who had a suspected periprosthetic knee infection. Furthermore, the diagnostic accuracy of the proposed threshold was evaluated. Materials and methods Between January 2020 and April 2022, patients with failed or painful knee arthroplasty who were admitted to a tertiary referral institution undergoing the standardized diagnostic protocol to identify those with a periprosthetic joint infection (PJI) were analyzed. The 2018 International Consensus Meeting (ICM) criteria were used to classify patients with PJIs and aseptic joints. Sensitivity, specificity, positive predictive value, negative predictive value, and the area under the receiver operating characteristic (ROC) curve (AUC) of AGR were calculated to define the test’s diagnostic accuracy. Results The ROC curve showed that the optimal cutoff value of AGR was 1.43. AGR registered a sensitivity of 95% (95% CI 91–197%), a specificity of 63% (95% CI 56–69%), a positive predictive value of 75% (95% CI 69–81%), and a negative predictive value of 91% (95% CI 86–94%). Receiver operator curve analysis demonstrated an AUC of 0.85 (95% CI 0.77–0.88). Although body mass index (BMI), uremia, glutamic-oxaloacetic transaminase (GOT), international normalized ratio (INR), and alkaline phosphatase showed significant differences between the false positive cases and those cases affected by aseptic failure with AGR higher than 1.43, indicating potential confounding effects ( p  < 0.05), no parameter was found to be a significant predictor of false positives cases ( p  > 0.05). Conclusions For its high sensitivity, AGR showed potential as a screening tool for detecting infections in PJI diagnostics. Level of evidence : III.

• Publisher: Springer International Publishing,Springer Nature B.V,SpringerOpen
• Subject: Accuracy / Aged / Aged, 80 and over / Albumin / Albumins / Alkaline phosphatase / Arthritis / Arthroplasty (knee) / Arthroplasty, Replacement, Knee - adverse effects / Biomarkers / Biomarkers - blood / Blood / Body mass index / Body size / C-reactive protein / Comorbidity / Conservative Orthopedics / Diagnostic / Female / Globulin / Globulins / Humans / Infections / Joint diseases / Joint replacement surgery / Knee / Knee Prosthesis - adverse effects / Leukocytes / Male / Medicine / Medicine & Public Health / Middle Aged / Original / Original Article / Orthopedics / Patients / Performance evaluation / PJI / Predictive Value of Tests / Prosthesis-Related Infections - blood / Prosthesis-Related Infections - diagnosis / Retrospective Studies / Rheumatology / ROC Curve / Sensitivity / Sensitivity and Specificity / Serum Albumin - analysis / Serum Globulins - analysis / Serum markers / Software / Sports Medicine / Surgical Orthopedics / Total knee arthroplasty / Transaminase / Traumatic Surgery / Uremia