Asset Details
Do you wish to reserve the book?
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
Do you wish to request the book?
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
2025
Overview
Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that account for their biological differences. Here we show using single cell analysis that HVs harbor a tumor cell state characterized by expression of
MUC16
(CA125),
MUC4
, and
KRT24
. This cell state is enriched in metastases, predicted to be highly resistant to chemotherapy, and linked with poor survival. We also find enriched expression of
TM4SF1
, a transmembrane protein, in HV tumor cells. Chimeric antigen receptor (CAR) T cells engineered against TM4SF1 protein demonstrated in vitro and in vivo activity against bladder cancer cell lines in a
TM4SF1
expression-dependent manner, highlighting its potential as a therapeutic target.
Single cell analysis of histologic variant bladder tumors detects a shared CA125+ tumor cell state associated with aggressive clinical features and reveals enriched expression of TM4SF1, a membrane protein that can be targeted with CAR T cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/51
/ 45/91
/ Animals
/ Bladder
/ Cancer
/ Female
/ Gene Expression Regulation, Neoplastic
/ Humanities and Social Sciences
/ Humans
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - metabolism
/ Proteins
/ Science
/ Tumors
/ Urinary Bladder Neoplasms - genetics
/ Urinary Bladder Neoplasms - metabolism
/ Urinary Bladder Neoplasms - pathology
