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Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways
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Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways
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Journal Article
Vorinostat attenuates UVB-induced skin senescence by modulating NF-κB and mTOR signaling pathways
2025
Overview
Excessive exposure to ultraviolet B (UVB) radiation induces oxidative stress and inflammatory responses, accelerating the senescence process of skin cells. Vorinostat (SAHA), a histone deacetylase inhibitor (HDACi), is typically administered to patients with peripheral T-cell lymphoma, cutaneous T-cell lymphoma, or multiple myeloma. However, its effect on UVB-induced skin photoaging remains unclear. In this study, we used UVB to induce senescence in human immortalized keratinocyte cell line (HaCaT cells) and skin photoaging in Balb/c mice to investigate the potential of SAHA in mitigating photoaging. First, we established a UVB-induced photoaging model in HaCaT cells. We observed that UVB exposure significantly upregulated the activity of senescence-associated β-galactosidase, p16, p21, IL-1β, IL-6, and matrix metalloproteinases [collagenase (MMP-1), matrix metalloproteinase-3 (MMP-3), and gelatinase (MMP-9)]. Supplementation with SAHA effectively alleviated cellular senescence in HaCaT cells. Next, we used UVB to induce photoaging in Balb/c mouse skin. The study demonstrated that UVB markedly caused skin senescence in Balb/c mice, while SAHA effectively mitigated the changes induced by UVB irradiation. Mechanistically, we found that UVB activated the mammalian target of rapamycin (mTOR) and nuclear factor-κB (NF-κB) signaling pathways, whereas SAHA inhibited the upregulation of both mTOR and NF-κB. In summary, these findings suggest that SAHA may protect against UVB-induced cellular senescence and skin photoaging by inhibiting the mTOR and NF-κB signaling pathways. Therefore, SAHA could be a potential anti-senescence agent for mitigating skin photoaging.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/337
/ 631/601
/ 631/80
/ 692/308
/ 692/420
/ 692/699
/ Animals
/ Cellular Senescence - drug effects
/ Cellular Senescence - radiation effects
/ Histone Deacetylase Inhibitors - pharmacology
/ Humanities and Social Sciences
/ Humans
/ Keratinocytes - drug effects
/ Keratinocytes - radiation effects
/ Lymphoma
/ Mice
/ mTOR
/ NF-κB
/ Science
/ Signal Transduction - drug effects
/ Signal Transduction - radiation effects
/ Skin
/ Skin Aging - radiation effects
/ TOR Serine-Threonine Kinases - metabolism
