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Relationship between bile salt hydrolase activity, changes in the internal pH and tolerance to bile acids in lactic acid bacteria
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Relationship between bile salt hydrolase activity, changes in the internal pH and tolerance to bile acids in lactic acid bacteria
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Journal Article
Relationship between bile salt hydrolase activity, changes in the internal pH and tolerance to bile acids in lactic acid bacteria
2012
Overview
The effect of the conjugated bile acid (BA) on the microbial internal pH (pHin) values in lactic acid bacteria with and without ability to hydrolyze bile salts (BSH[+] and BSH[−] strains, respectively) was evaluated. BSH(+) strains showed a gradual increase in the pHin following the addition of conjugated BA; this behavior was more pronounced with GDCA than with TDCA may be due to the higher affinity of BSH for the glyco-conjugates acids. Conversely, the BSH(−) strains showed a decrease in internal pH probably as a consequence of weak acid accumulation. As expected, a decrease in the cytoplasmatic pH affected the cell survival in this last group of strains, while the BSH(+) strains were more resistant to the toxic effect of BA. PURPOSE OF WORK: To evaluate bile salt hydrolase activities, changes in the internal pH and cell survival to bile acids in lactic acid bacteria to establish the relationship between these parameters.
Publisher
Springer-Verlag,Springer Netherlands,Springer,Springer Nature B.V
Subject
/ Amidohydrolases - metabolism
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Bile
/ Bile Acids and Salts - metabolism
/ Bile Acids and Salts - pharmacology
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ genetics
/ Intracellular Space - chemistry
/ Intracellular Space - enzymology
/ Lactobacillales - drug effects
/ Lactobacillales - enzymology
/ Lactobacillales - metabolism
/ Strain
/ Survival
/ Toxicity
