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TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection
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TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection
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Journal Article
TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection
2020
Overview
Excessive tumor necrosis factor (TNF) is known to cause significant pathology. Paradoxically, deficiency in TNF (TNF−/−) also caused substantial pathology during respiratory ectromelia virus (ECTV) infection, a surrogate model for smallpox. TNF−/− mice succumbed to fulminant disease whereas wild-type mice, and those engineered to express only transmembrane TNF (mTNF), fully recovered. TNF deficiency did not affect viral load or leukocyte recruitment but caused severe lung pathology and excessive production of the cytokines interleukin (IL)-6, IL-10, transforming growth factor beta (TGF-β), and interferon gamma (IFN-γ). Short-term blockade of these cytokines significantly reduced lung pathology in TNF−/− mice concomitant with induction of protein inhibitor of activated STAT3 (PIAS3) and/or suppressor of cytokine signaling 3 (SOCS3), factors that inhibit STAT3 activation. Consequently, inhibition of STAT3 activation with an inhibitor reduced lung pathology. Long-term neutralization of IL-6 or TGF-β protected TNF−/− mice from an otherwise lethal infection. Thus, mTNF alone is necessary and sufficient to regulate lung inflammation but it has no direct antiviral activity against ECTV. The data indicate that targeting specific cytokines or cytokine-signaling pathways to reduce or ameliorate lung inflammation during respiratory viral infections is possible but that the timing and duration of the interventive measure are critical.
Publisher
National Academy of Sciences
Subject
/ Animals
/ Female
/ Interferon-gamma - metabolism
/ Lungs
/ Mice
/ Poxviridae Infections - immunology
/ Poxviridae Infections - pathology
/ Poxviridae Infections - virology
/ Respiratory Tract Infections - immunology
/ Respiratory Tract Infections - virology
/ Smallpox
/ STAT3 Transcription Factor - genetics
/ STAT3 Transcription Factor - metabolism
/ Suppressor of Cytokine Signaling 3 Protein - metabolism
/ Transforming Growth Factor beta - metabolism
/ Transforming growth factor-b
/ Tumor Necrosis Factor-alpha - genetics
/ Tumor Necrosis Factor-alpha - metabolism
/ Viruses
