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Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma
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Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma
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Journal Article
Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma
2015
Overview
Hypoxic microenvironment is a powerful driving force for the invasion and metastasis of hepatocellular carcinoma (HCC). Hypoxia-inducible factor 1α (HIF-1α), as a crucial regulator of transcriptional responses to hypoxia, induces the expression of multiple target genes involved in different steps of HCC metastatic process. It is critical to find target genes associated with metastasis under hypoxia for shedding new light on molecular mechanism of HCC metastasis. In this study, we uncovered that hypoxia could induce the upregulation of Rab11-family interacting protein 4 (Rab11-FIP4) and activation of Rab11-FIP4 promoter by HIF-1α. The overexpression of Rab11-FIP4 significantly enhanced the mobility and invasiveness of HCC cells
in vitro
, also contributed to distant lung metastasis
in vivo
, whereas silencing of Rab11-FIP4 decreased the ability of migration and invasion in HCC cells
in vitro
and suppressed lung metastasis
in vivo
. Rab11-FIP4 facilitated HCC metastasis through the phosphorylation of PRAS40, which was regulated by mTOR. Furthermore, the expression level of Rab11-FIP4 was significantly increased in HCC tissues and high expression of Rab11-FIP4 was closely correlated with vascular invasion and poor prognosis in HCC patients. A markedly positive correlation between the expression of Rab11-FIP4 and HIF-1α was observed in HCC tissues and combination of Rab11-FIP4 and HIF-1α was a more valuable predictor of poor prognosis for HCC patients. In conclusion, Rab11-FIP4 is a target gene of HIF-1α and has a pro-metastatic role in HCC, suggesting that Rab11-FIP4 may be a promising candidate target for HCC treatment.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
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/ 38
/ 38/1
/ 38/22
/ 38/23
/ 38/39
/ 38/44
/ 38/70
/ 38/77
/ 38/90
/ 45
/ 45/29
/ 82
/ 82/80
/ Animals
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - metabolism
/ Carcinoma, Hepatocellular - pathology
/ Carrier Proteins - metabolism
/ Complications and side effects
/ Female
/ Gene Expression Regulation, Neoplastic
/ Hepatoma
/ Humans
/ Hypoxia
/ Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
/ Kinases
/ Liver Neoplasms - metabolism
/ Male
/ Medicine
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ Oncology
