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Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
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Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
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Journal Article
Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
2020
Overview
Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin. Pepsin positivity is associated with nodal involvement, suggesting that pepsin may have a role in metastasis. Treatment of FaDu cancer cells with pepsin increased cell proliferation, possibly by inducing G1/S transition. We also observed significant changes in expression of genes involved in NF-kappaB, TRAIL and Notch signaling. Our data suggest that pepsin plays an important role in HPSCC and that targeting pepsin could have potential therapeutic benefits.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Cancer
/ Carcinoma, Squamous Cell - metabolism
/ Carcinoma, Squamous Cell - pathology
/ Female
/ G1 Phase
/ Gene Expression Regulation, Neoplastic
/ Humans
/ Laryngeal Neoplasms - metabolism
/ Laryngeal Neoplasms - pathology
/ Male
/ Medicine and Health Sciences
/ Neoplasm Proteins - metabolism
/ Pepsin
/ Pharyngeal Neoplasms - metabolism
/ Pharyngeal Neoplasms - pathology
/ Research and Analysis Methods
/ S Phase
/ Surgery
