Journal Article

Lipophilic Toxins in Chile: History, Producers and Impacts

Álvarez, Gonzalo, Blanco, Juan, Reguera, Beatriz, Díaz, Patricio A., Pizarro, Gemita

2022

Overview

A variety of microalgal species produce lipophilic toxins (LT) that are accumulated by filter-feeding bivalves. Their negative impacts on human health and shellfish exploitation are determined by toxic potential of the local strains and toxin biotransformations by exploited bivalve species. Chile has become, in a decade, the world’s major exporter of mussels (Mytilus chilensis) and scallops (Argopecten purpuratus) and has implemented toxin testing according to importing countries’ demands. Species of the Dinophysis acuminata complex and Protoceratium reticulatum are the most widespread and abundant LT producers in Chile. Dominant D. acuminata strains, notwithstanding, unlike most strains in Europe rich in okadaic acid (OA), produce only pectenotoxins, with no impact on human health. Dinophysis acuta, suspected to be the main cause of diarrhetic shellfish poisoning outbreaks, is found in the two southernmost regions of Chile, and has apparently shifted poleward. Mouse bioassay (MBA) is the official method to control shellfish safety for the national market. Positive results from mouse tests to mixtures of toxins and other compounds only toxic by intraperitoneal injection, including already deregulated toxins (PTXs), force unnecessary harvesting bans, and hinder progress in the identification of emerging toxins. Here, 50 years of LST events in Chile, and current knowledge of their sources, accumulation and effects, are reviewed. Improvements of monitoring practices are suggested, and strategies to face new challenges and answer the main questions are proposed.

• Publisher: MDPI AG,MDPI
• Subject: Algae / Animals / Argopecten purpuratus / Bio-assays / Bioassays / Biological Assay - methods / Biotransformation / Bivalvia / Bivalvia - chemistry / Bivalvia - metabolism / Chile / Control methods / Deregulation / Diarrhetic shellfish poisoning / Dinophysis acuminata / Dinophysis acuta / Europe / Exploitation / Filter feeders / HAB monitoring / harmful algal blooms / human health / Humans / intraperitoneal injection / Lipophilic / lipophilic toxins / Lipophilicity / Marine molluscs / Marine Toxins - isolation & purification / Marine Toxins - toxicity / markets / Mice / microalgae / Microalgae - metabolism / Microorganisms / Mollusks / Mussels / Mytilus chilensis / Okadaic acid / Paralytic shellfish poisoning / Pectenotoxins / Poisoning / Public health / Review / Scallops / Shellfish / Shellfish Poisoning - prevention & control / Species / Toxicity / Toxins / Water quality