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Adhesion signaling by a novel mitotic substrate of src kinases
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Adhesion signaling by a novel mitotic substrate of src kinases
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Journal Article
Adhesion signaling by a novel mitotic substrate of src kinases
2005
Overview
Src kinases are activated and relocalize to the cytoplasm during mitosis, but their mitotic function has remained elusive. We describe here a novel mitotic substrate of src kinases. Trask (
tr
ansmembrane and
a
ssociated with
s
rc
k
inases) is a 140 kDa type I transmembrane glycoprotein unrelated to currently known protein families. Src kinases phosphorylate Trask
in vitro
and mediate its mitotic hyperphosphorylation
in vivo
. Trask associates with both yes and src, is localized to the cell membrane during interphase, and undergoes cytoplasmic relocalization during mitosis. Overexpression of Trask leads to cell rounding and a loss of adhesion phenotype. Consistent with a function in cell adhesion, Trask interacts with a number of adhesion and matrix proteins including cadherins, syndecans, and the membrane-type serine protease 1 (MT-SP1), and is proteolytically cleaved by MT-SP1. Trask is unique among cell adhesion molecules in that it is under cell cycle regulation and thus links src kinases with the mitotic regulation of cell adhesion. This suggests a potential pathway by which hyperactive src kinases in tumors can deregulate adhesion signaling and mediate the metastatic phenotype.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Cell Adhesion Molecules - isolation & purification
/ Cell Adhesion Molecules - metabolism
/ Cell Adhesion Molecules - physiology
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Kinases
/ Medicine
/ Mitosis
/ Molecular and cellular biology
/ Oncology
/ Proteins
/ src-Family Kinases - physiology
/ Syndecan
/ Tumors
