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Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
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Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
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Journal Article
Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation
2025
Overview
Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED
50
) and adverse reactions of ciprofol and propofol, in conjunction with sufentanil, for suppressing cardiovascular responses during tracheal intubation. Fifty-three adult patients scheduled for tracheal intubation under general anesthesia were enrolled and randomly assigned to receive either ciprofol (Group C) or propofol (Group P), according to a random number table. Tracheal intubation was performed using a standardized laryngoscope and endotracheal tube. The Dixon’s up-and-down method was employed to determine the ED
50
and 95% effective dose (ED
95
) of ciprofol and propofol in inhibiting cardiovascular responses during tracheal intubation. Based on the pilot study, the initial dose for ciprofol was set at 0.35 mg/kg (with a 0.01 mg/kg increment) and for propofol at 2.0 mg/kg (with a 0.1 mg/kg increment). Probit analysis was applied to derive dose-response curves, while adverse reactions were continuously monitored. A total of 54 participants were included, with 24 in group C (1 excluded) and 30 in group P. Probit analysis revealed that the ED
50
of ciprofol for inhibiting cardiovascular responses to tracheal intubation were 0.326 mg/kg (95% CI 0.304–0.337 mg/kg), and for propofol, 1.541 mg/kg (95% CI 1.481–1.599 mg/kg). The heart rate in group P was significantly higher than the group C at 1 minute (
p
= 0.026) and 3 minutes (
p
= 0.016) post-intubation. Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups (
p
< 0.05). Group C experienced significantly less injection pain (
p
= 0.001), although the incidence of other adverse effects was not statistically different between groups (
p
> 0.05).
Clinical Trial Registration
: hppts://ClinicalTrials.gov; Identifier: NCT06095570(18/10/2023).
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/308
/ 692/698
/ 692/699
/ Adult
/ Aged
/ Anesthetics, Intravenous - administration & dosage
/ Blood Pressure - drug effects
/ Ciprofol
/ Dose-Response Relationship, Drug
/ Female
/ Humanities and Social Sciences
/ Humans
/ Intubation, Intratracheal - adverse effects
/ Intubation, Intratracheal - methods
/ Male
/ Pain
/ Propofol
/ Propofol - administration & dosage
/ Science
