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Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
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Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
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Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
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Journal Article
Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
2020
Overview
Odor landscapes contain complex blends of molecules that each activate unique, overlapping populations of olfactory sensory neurons (OSNs). Despite the presence of hundreds of OSN subtypes in many animals, the overlapping nature of odor inputs may lead to saturation of neural responses at the early stages of stimulus encoding. Information loss due to saturation could be mitigated by normalizing mechanisms such as antagonism at the level of receptor-ligand interactions, whose existence and prevalence remains uncertain. By imaging OSN axon terminals in olfactory bulb glomeruli as well as OSN cell bodies within the olfactory epithelium in freely breathing mice, we find widespread antagonistic interactions in binary odor mixtures. In complex mixtures of up to 12 odorants, antagonistic interactions are stronger and more prevalent with increasing mixture complexity. Therefore, antagonism is a common feature of odor mixture encoding in OSNs and helps in normalizing activity to reduce saturation and increase information transfer.
Odor blends contain molecules that activate unique, overlapping populations of sensory neurons (OSNs). Here, by imaging OSN axon terminals, as well as their cell bodies within the olfactory epithelium, the authors find widespread antagonistic interactions in binary and complex odor mixtures.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/69
/ Animals
/ Complex Mixtures - pharmacology
/ Female
/ Humanities and Social Sciences
/ Ligands
/ Male
/ Mice
/ Microscopy, Fluorescence, Multiphoton
/ Mixtures
/ Neurons
/ Odorants
/ Odors
/ Olfactory Bulb - diagnostic imaging
/ Olfactory Mucosa - drug effects
/ Olfactory Mucosa - metabolism
/ Olfactory Perception - drug effects
/ Olfactory Perception - physiology
/ Olfactory Receptor Neurons - drug effects
/ Olfactory Receptor Neurons - physiology
/ Physics
/ Presynaptic Terminals - physiology
/ Receptors, Odorant - metabolism
/ Science
/ Smell
