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Titanium-prepared platelet-rich fibrin enhances alveolar ridge preservation: a randomized controlled clinical and radiographic study
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Titanium-prepared platelet-rich fibrin enhances alveolar ridge preservation: a randomized controlled clinical and radiographic study
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Journal Article
Titanium-prepared platelet-rich fibrin enhances alveolar ridge preservation: a randomized controlled clinical and radiographic study
2025
Overview
This randomized controlled trial evaluated the efficacy of titanium-prepared platelet-rich fibrin (T-PRF) for alveolar ridge preservation (ARP) compared with leukocyte and platelet rich fibrin (L-PRF) and spontaneous healing. Thirty single-rooted teeth requiring extraction were randomly assigned to one of three groups (ARP with T-PRF, ARP with L-PRF, and spontaneous healing) using a flapless, atraumatic extraction approach. Radiographic measurements (bone width, height, and density) were obtained pre-operatively and at four months via OnDemand3D software, and clinical parameters—including post-operative pain, analgesic consumption, soft-tissue healing, periodontal probing depth, gingival recession, and keratinized tissue width—were assessed. At four months, the T-PRF group demonstrated substantially greater preservation of ridge dimensions (
P
= 0.000), and higher bone density (
P
= 0.000), along with improved soft-tissue healing (
P
< 0.05), lower pain scores (
P
= 0.000), and reduced analgesic use (
P
< 0.05). Periodontal parameters remained stable across the groups, except for keratinized tissue width (KTW), which was substantially greater in the T-PRF group (
P
= 0.020). There were substantial differences among the groups in the need for bone regeneration when implants were placed (
P
< 0.05). These findings support the clinical advantage of T-PRF in optimizing post-extraction outcomes for implant site development.
This trial was registered in the UK’s Clinical Study Registry ISRCTN (ISRCTN60191547).
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Alveolar Bone Loss - prevention & control
/ Alveolar Process - diagnostic imaging
/ Alveolar Process - drug effects
/ Alveolar Ridge Augmentation - methods
/ Female
/ Fibrin
/ Humanities and Social Sciences
/ Humans
/ Male
/ Pain
/ Patients
/ Platelet-Rich Fibrin - metabolism
/ Science
/ Software
/ Sutures
/ Teeth
/ Titanium
