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Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy
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Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy
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Journal Article
Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy
2024
Overview
This study explores the role of the vaginal microbiota (VM) in the pathophysiology of asymptomatic bacteriuria (ASB) in a cohort of 1,553 pregnant women. Worldwide,
E. coli
remains the most common etiological agent of bacteriuria during pregnancy and also a major causative agent of newborn infections. A healthy VM is typically characterized by low diversity and is dominated by lactic acid-producing species, notably those from the
Lactobacillus
genus. Our results point to decreases in
Lactobacillus spp
associated with an increase of gut-microbiota-associated species from the Enterobacterales order.
Escherichia coli
exhibited the most pronounced increase in abundance within the VM during bacteriuria and was notably associated with ASB. Molecular typing and antimicrobial resistance characterization of 72 metagenome assembled
E. coli
genomes (MAGs) from these pregnant women revealed a genomic signature of extraintestinal pathogenic
E. coli
(“ExPEC”) strains, which are involved in various extraintestinal infections such as urinary tract infections, newborn infections and bacteremia. Microbial diversity within the vaginal samples from which an
E. coli
MAG was obtained showed a substantial variation, primarily marked by a decrease in abundance of
Lactobacillus
species. Overall, our study shows how disruption in key bacterial group within the VM can disrupt its stability, potentially leading to the colonization by opportunistic pathogens.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ E coli
/ Enterobacteriaceae - metabolism
/ Escherichia coli - metabolism
/ Escherichia coli Infections - microbiology
/ Extra-intestinal pathogenic E. Coli (ExPEC)
/ Female
/ Humanities and Social Sciences
/ Humans
/ Pregnancy Complications, Infectious - microbiology
/ Reproductive Tract Infections
/ Science
/ Urinary tract infection (UTI)
/ Vagina
