Journal Article

Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant

Sheen, J, Jones, T.L, Jang, J.C, Zhou, L. (Harvard Medical School, Boston, MA.)

1998

Overview

Glucose is an essential signaling molecule that controls plant development and gene expression through largely unknown mechanisms. To initiate the dissection of the glucose signal transduction pathway in plants by using a genetic approach, we have identified an Arabidopsis mutant, gin1, (glucose-insensitive), in which glucose repression of cotyledon greening and expansion, shoot development, floral transition, and gene expression is impaired. Genetic analysis indicates that GIN1 acts downstream of the sensor hexokinase in the glucose signaling pathway. Surprisingly, gin1 insensitivity to glucose repression of cotyledon and shoot development is phenocopied by ethylene precursor treatment of wild-type plants or by constitutive ethylene biosynthesis and constitutive ethylene signaling mutants. In contrast, the ethylene insensitive mutant etr1-1 exhibits glucose hypersensitivity. Epistasis analysis places GIN1 downstream of the ethylene receptor, ETR1, and defines a new branch of ethylene signaling pathway that is uncoupled from the triple response induced by ethylene. The isolation and characterization of gin1 reveal an unexpected convergence between the glucose and the ethylene signal transduction pathways. GIN1 may function to balance the control of plant development in response to metabolic and hormonal stimuli that act antagonistically

• Publisher: National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences,The National Academy of Sciences
• Subject: ABSORCION DE SUSTANCIAS NUTRITIVAS / ABSORPTION DE SUBSTANCES NUTRITIVES / ALLELES / Arabidopsis / Arabidopsis - genetics / Arabidopsis - growth & development / Arabidopsis - metabolism / ARABIDOPSIS THALIANA / Biological Sciences / Biological Transport, Active / COTILEDONES / COTYLEDON / COTYLEDONS / CRECIMIENTO / CROISSANCE / EPISTASIS / ETHYLENE / Ethylenes / Ethylenes - metabolism / ETILENO / EXPRESION GENICA / EXPRESSION DES GENES / FENOTIPOS / FISIOLOGIA VEGETAL / FLORACION / FLORAISON / FLOWERING / Flowers & plants / GENE / GENE EXPRESSION / Gene Expression Regulation, Developmental / Gene Expression Regulation, Plant / GENE INTERACTION / GENE RECESSIF / GENES / GENES RECESIVOS / Genes, Plant / GENETIC ANALYSIS / genetic techniques and protocols / GENETICA / GENETICS / GENETIQUE / Gin / GIN1 GENE / GLUCOSA / GLUCOSE / Glucose - metabolism / Glucose - pharmacology / GREENING / GROWTH / growth & development / INTERACCION DE GENES / INTERACTION GENIQUE / LOCI / LOCUS / metabolism / Molecules / MUTANT / MUTANTES / MUTANTS / Mutation / NUTRIENT UPTAKE / pharmacology / PHENOTYPE / PHENOTYPES / Photosynthesis / Photosynthesis - genetics / PHYSIOLOGIE VEGETALE / Plant cells / PLANT PHYSIOLOGY / Plants / PLANTULAS / PLANTULE / PROTOPLASTE / PROTOPLASTOS / PROTOPLASTS / RECESSIVE GENES / REGULATION / seedling growth / SEEDLINGS / SEGREGACION / SEGREGATION / shoots / Signal Transduction / STEMS / TALLO / TEMPS / TIEMPO / TIGE / TIME