Asset Details
Do you wish to reserve the book?
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
Do you wish to request the book?
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
2019
Overview
The human fungal pathogen
Candida glabrata
appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathogen of glucose, and therefore alternative carbon sources probably support the growth and survival of engulfed
C. glabrata
. The present study aimed to investigate the role of the glyoxylate cycle gene
ICL1
in alternative carbon utilisation and its importance for the virulence of
C. glabrata
. The data showed that disruption of
ICL1
rendered
C. glabrata
unable to utilise acetate, ethanol or oleic acid. In addition,
C. glabrata icl1
∆ cells displayed significantly reduced biofilm growth in the presence of several alternative carbon sources. It was also found that
ICL1
is crucial for the survival of
C. glabrata
in response to macrophage engulfment. Disruption of
ICL1
also conferred a severe attenuation in the virulence of
C. glabrata
in the mouse model of invasive candidiasis. In conclusion, a functional glyoxylate cycle is essential for
C. glabrata
to utilise certain alternative carbon sources
in vitro
and to display full virulence
in vivo
. This reinforces the view that antifungal drugs that target fungal
Icl1
have potential for future therapeutic intervention.
Publisher
Nature Publishing Group UK,Nature Publishing Group
