Asset Details
Do you wish to reserve the book?
Cyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Cyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans
Do you wish to request the book?
Cyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Cyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans
2025
Overview
P2 × 7R is crucial in the pathogenesis of chronic inflammatory diseases, and its activation leads to the release of pro-inflammatory cytokines, exacerbating the inflammatory response. Two new series of scarce cyclic
N
,
O
-acetals (ATF 61–74) and corresponding opened
N
,
N
-aminals (CS 1–14) have been designed as novel potential P2RX7 antagonists, then synthesized and evaluated for their anti-inflammatory properties through investigating the pro-inflammatory markers and also for their antifungal activity against
Candida albicans
. Three compounds (ATF 64, CS 8, and CS 9) exhibited dual antifungal and anti-inflammatory properties. ATF 64, CS 8, and CS 9 reduced ROS production and IL-1β expression in macrophages and intestinal cells in a manner correlated with NF-KB expression. These compounds showed excellent antifungal activity against clinical isolates of
C. albicans
resistant to fluconazole and caspofungin, and reduced
C. albicans
biofilm formation. Treatment with CS 8 or CS 9 protected the nematode
Caenorhabditis elegans
against infection with
C. albicans
and enhanced antimicrobial gene expression. This duality of action offers a promising new pharmacological strategy to counteract inflammatory diseases and propels
N
,
N
-aminals as promising candidates for future optimization and investigation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Acetals - chemical synthesis
/ Animals
/ Anti-Inflammatory Agents - chemical synthesis
/ Anti-Inflammatory Agents - chemistry
/ Anti-Inflammatory Agents - pharmacology
/ Antifungal Agents - chemical synthesis
/ Antifungal Agents - chemistry
/ Antifungal Agents - pharmacology
/ Biofilms
/ Caenorhabditis elegans - drug effects
/ Caenorhabditis elegans - microbiology
/ Candida albicans - drug effects
/ Humanities and Social Sciences
/ Humans
/ Interleukin-1beta - metabolism
/ Mice
/ Reactive Oxygen Species - metabolism
/ Science
