Asset Details
Do you wish to reserve the book?
Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice
Do you wish to request the book?
Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice
2020
Overview
Blueberries are a rich source of polyphenols, widely studied for the prevention or attenuation of metabolic diseases. However, the health contribution and mechanisms of action of polyphenols depend on their type and structure. Here, we evaluated the effects of a wild blueberry polyphenolic extract (WBE) (
Vaccinium angustifolium
Aiton) on cardiometabolic parameters, gut microbiota composition and gut epithelium histology of high-fat high-sucrose (HFHS) diet-induced obese mice and determined which constitutive polyphenolic fractions (BPF) was responsible for the observed effects. To do so, the whole extract was separated in three fractions, F1) Anthocyanins and phenolic acids, F2) oligomeric proanthocyanidins (PACs), phenolic acids and flavonols (PACs degree of polymerization DP < 4), and F3) PACs polymers (PACs DP > 4) and supplied at their respective concentration in the whole extract. After 8 weeks, WBE reduced OGTT AUC by 18.3% compared to the HFHS treated rodents and the F3 fraction contributed the most to this effect. The anthocyanin rich F1 fraction did not reproduce this response. WBE and the BPF restored the colonic mucus layer. Particularly, the polymeric PACs-rich F3 fraction increased the mucin-secreting goblet cells number. WBE caused a significant 2-fold higher proportion of
Adlercreutzia equolifaciens
whereas oligomeric PACs-rich F2 fraction increased by 2.5-fold the proportion of
Akkermansia muciniphila
. This study reveals the key role of WBE PACs in modulating the gut microbiota and restoring colonic epithelial mucus layer, providing a suitable ecological niche for mucosa-associated symbiotic bacteria, which may be crucial in triggering health effects of blueberry polyphenols.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/63
/ 38/22
/ 38/23
/ 38/39
/ 38/77
/ 38/90
/ 45/23
/ 64
/ 64/60
/ 82/16
/ 82/58
/ Animals
/ Blueberry Plants - chemistry
/ Diet, High-Fat - adverse effects
/ Dietary Sucrose - adverse effects
/ Fruits
/ Gastrointestinal Microbiome - drug effects
/ Glucose Intolerance - drug therapy
/ Glucose Intolerance - etiology
/ Glucose Intolerance - metabolism
/ Glucose Intolerance - pathology
/ Humanities and Social Sciences
/ Humans
/ Intestinal Mucosa - drug effects
/ Intestinal Mucosa - microbiology
/ Intestinal Mucosa - pathology
/ Male
/ Mice
/ Mucin
/ Mucosa
/ Phenols
/ Plant Extracts - administration & dosage
/ Polymers
/ Proanthocyanidins - administration & dosage
/ Science
/ Sucrose
