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Parity associates with chromosomal damage in uterine leiomyomas
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Parity associates with chromosomal damage in uterine leiomyomas
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Parity associates with chromosomal damage in uterine leiomyomas
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Journal Article
Parity associates with chromosomal damage in uterine leiomyomas
2021
Overview
Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms that display relatively few chromosomal aberrations. We hypothesized that if mechanical forces contribute to chromosomal damage, signs of this could be seen in uterine leiomyomas from parous women. We examined the karyotypes of 1946 tumors, and found a striking overrepresentation of chromosomal damage associated with parity. We then subjected myometrial cells to physiological forces similar to those encountered during pregnancy, and found this to cause DNA breaks and a DNA repair response. While mechanical forces acting in constrained cellular environments may thus contribute to neoplastic degeneration, and genesis of uterine leiomyoma, further studies are needed to prove possible causality of the observed association. No evidence for progression to malignancy was found.
Many factors have been associated with chromosomal damage, including mechanical forces in a constrained cellular environment. Here the authors reveal an association between parity and chromosomal damage by analysing karyotypes of 1946 uterine leiomyomas.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 45
/ 45/23
/ Adult
/ Damage
/ DNA
/ Female
/ Fibroids
/ Humanities and Social Sciences
/ Humans
/ Mutation
/ Myocytes, Smooth Muscle - metabolism
/ Myocytes, Smooth Muscle - pathology
/ Parity
/ Science
/ Uterine Neoplasms - etiology
/ Uterine Neoplasms - genetics
/ Uterine Neoplasms - pathology
/ Uterus
