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Expression of Dux family genes in early preimplantation embryos
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Expression of Dux family genes in early preimplantation embryos
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Journal Article
Expression of Dux family genes in early preimplantation embryos
2020
Overview
After fertilization, the zygotic genome is activated through two phases, minor zygotic activation (ZGA) and major ZGA. Recently, it was suggested that DUX is expressed during minor ZGA and activates some genes during major ZGA. However, it has not been proven that
Dux
is expressed during minor ZGA and functions to activate major ZGA genes, because there are several
Dux
paralogs that may be expressed in zygotes instead of
Dux
. In this study, we found that more than a dozen
Dux
paralogs, as well as
Dux
, are expressed during minor ZGA. Overexpression of some of these genes induced increased expression of major ZGA genes. These results suggest that multiple
Dux
paralogs are expressed to ensure a sufficient amount of functional
Dux
and its paralogs which are generated during a short period of minor ZGA with a low transcriptional activity. The mechanism by which multiple
Dux
paralogs are expressed is discussed.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/601
/ Animals
/ Cloning
/ Embryos
/ Female
/ Gene Expression Regulation, Developmental - physiology
/ Genomes
/ Homeodomain Proteins - genetics
/ Homeodomain Proteins - metabolism
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Reverse Transcriptase Polymerase Chain Reaction
/ Science
/ Zygotes
