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Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases
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Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases
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Journal Article
Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases
2020
Overview
Immunoglobulin A nephropathy (IgAN) involves repeated events of gross haematuria with concurrent upper airway infections. The mucosal immune system, especially the tonsil, is considered the initial site of inflammation, although the role of the tonsillar microbiota has not been established in IgAN. In this study, we compared the tonsillar microbiota of patients with IgAN (n = 21) and other glomerular diseases (n = 36) as well as, healthy controls (n = 23) from three medical centres in Korea. The microbiota was analysed from tonsil swabs using the Illumina MiSeq system based on 16S rRNA gene. Tonsillar bacterial diversity was higher in IgAN than in other glomerular diseases, although it did not differ from that of healthy controls. Principal coordinates analysis revealed differences between the tonsillar microbiota of IgAN and both healthy and disease controls. The proportions of
Rahnella
,
Ruminococcus_g2
, and
Clostridium_g21
were significantly higher in patients with IgAN than in healthy controls (corrected p < 0.05). The relative abundances of several taxa were correlated with the estimated glomerular filtration rate, blood urea nitrogen, haemoglobin, and serum albumin levels. Based on our findings, tonsillar microbiota may be associated with clinical features and possible immunologic pathogenesis of IgAN.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/4022
/ Adult
/ Bacteria - isolation & purification
/ Bacterial Proteins - genetics
/ Female
/ Glomerulonephritis, IGA - genetics
/ Glomerulonephritis, IGA - microbiology
/ Humanities and Social Sciences
/ Humans
/ Kidney Diseases - microbiology
/ Male
/ Palatine Tonsil - metabolism
/ Palatine Tonsil - microbiology
/ Patients
/ RNA, Ribosomal, 16S - analysis
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
/ Tonsil
/ Urea
